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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62150
Doc. No : 811A
Main Entry : CHATTOPADHYAY P
Title & Author : PROTECTIVE EFFECT OF FOLIC ACID AGAINST APOPTOSIS INDUCED BY ISCHEMIA/REPERFUSION INJURY IN RAT LIVER [Article]; WAHI A.K.
Title : IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume Number : , Vol.3 ؛ No.4
Date : , (2007)
page : : 229 - 238
Abstract : The anti-apoptotic gene bcl-2 is located in mitochondria, but it is uncertain whether its expression affects hepatocyte survival in ischemia/reperfusion )I/R( injury. This experiment was designed to evaluate the role of folic acid in expression of bcl- 2 in I/R in rat liver. Eighteen Wister rats were divided into sham-operated control group )C( )n=6(, I/R group )n=6(, folic acid treated group which received 1 mg/kg/day folic acid by oral route for 7 days before induction of I/R )n=6(. Bcl-2 expression was measured by RT-PCR and western blot methods. Folic acid significantly increased Bcl-2 mRNA expression in comparison to the I/R group. Quantification of apoptotic and necrotic hepatocytes, measured by fluorescence microscopy and terminal deoxynucleotidyl transferase )TdT(-mediated dUDPbiotin nick end labeling )TUNEL( method, showed a significant decrease in apoptosis and necrosis of hepatocytes in folic acid-treated group. Histopathological examination of the liver revealed that folic acid protected from severe hepatic degeneration from I/R injury. The biochemical parameters like alanine transaminases and aspartate transaminases were significantly decreased in folic acid-treated group compared to I/R group. In conclusion, folic acid afforded significant protection against I/R injury due to its ability to inhibit I/R-induced apoptosis.
Descriptor : APOPTOSIS
Descriptor : BCL-2 GENE
Descriptor : ISCHEMIC/REPERFUSION INJURY The anti-apoptotic gene bcl-2 is located in mitochondria
Descriptor : but it is uncertain whether its expression affects hepatocyte survival in ischemia/reperfusion (I/R) injury. This experiment was designed to evaluate the role of folic acid in expression of bcl- 2 in I/R in rat liver. Eighteen Wister rats were divided into sham-operated control group (C) (n=6)
Descriptor : I/R group (n=6)
Descriptor : folic acid treated group which received 1 mg/kg/day folic acid by oral route for 7 days before induction of I/R (n=6). Bcl-2 expression was measured by RT-PCR and western blot methods. Folic acid significantly increased Bcl-2 mRNA expression in comparison to the I/R group. Quantification of apoptotic and necrotic hepatocytes
Descriptor : measured by fluorescence microscopy and terminal deoxynucleotidyl transferase (TdT)-mediated dUDPbiotin nick end labeling (TUNEL) method
Descriptor : showed a significant decrease in apoptosis and necrosis of hepatocytes in folic acid-treated group. Histopathological examination of the liver revealed that folic acid protected from severe hepatic degeneration from I/R injury. The biochemical parameters like alanine transaminases and aspartate transaminases were significantly decreased in folic acid-treated group compared to I/R group. In conclusion
Descriptor : folic acid afforded significant protection against I/R injury due to its ability to inhibit I/R-induced apoptosis. Keyword: APOPTOSIS
Descriptor : BCL-2 GENE
Descriptor : ISCHEMIC/REPERFUSION INJURY The anti-apoptotic gene bcl-2 is located in mitochondria
Descriptor : but it is uncertain whether its expression affects hepatocyte survival in ischemia/reperfusion (I/R) injury. This experiment was designed to evaluate the role of folic acid in expression of bcl- 2 in I/R in rat liver. Eighteen Wister rats were divided into sham-operated control group (C) (n=6)
Descriptor : I/R group (n=6)
 
 
 
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