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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62161
Doc. No : 822A
Main Entry : KARIMI G.R.
Title & Author : PROTECTIVE EFFECTS OF LYCOPENE AND TOMATO EXTRACT AGAINST DOXORUBICIN-INDUCED CARDIOTOXICITY [Article]
Title : IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume Number : , Vol.1 ؛ No.2
Date : , (2005)
page : : 85 - 90
Abstract : The protective effect of tomato extract and lycopene on acute doxorubicin-induced myocardial toxicity was evaluated in mice. Doxorubicin toxicity, induced by a single intraperitoneal injection )15 mg/kg(, was revealed by elevated serum CPKMB and histopathological observations. Tomato extract )1.2 and 2.4 g/kg, i.p.( and lycopene )1.7 and 3.5 mg/kg, i.p.(, prevented the rise in serum CPKMB and ameliorated cardiac cell injury. These results suggest that tomato extract and lycopene inhibit doxorubicin-induced cardiotoxicity and might serve as a combination chemotherapeutic agent with doxorubicin to limit its cardiotoxic effects.
Descriptor : DOXORUBICIN
Descriptor : CARDIOTOXICITY
Descriptor : TOMATO
Descriptor : LYCOPENE
Added Entry : RAMEZANI MOHAMMAD
: ABDI A.
 
 
 
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