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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62263
Doc. No : 925A
Main Entry : ASHRAFUL ALAM MD
Title & Author : STUDIES OF IN-VITRO AMLODIPINE AND ARSENIC DISPLACEMENT INTERACTION AT BINDING SITES OF BOVINE SERUM ALBUMIN [Article]; SIKDER M.H.,MAHBUBUL ALAM S.M.,MOSTOFA M.,UDDIN SH.J.
Title : IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)
Volume Number : , Vol.7 ؛ No.1
Date : , (2008)
page : : 1 - 8
Abstract : In this study, the binding of amlodipine )a Calcium channel Blocker( and arsenic )metalloid( to bovine serum albumin )BSA( was studied by equilibrium dialysis)ED( method in order to have an insight into their binding chemistry to BSA. Free amlodipine concentration was increased due to addition of arsenic which reduced the binding of the compounds to BSA. However, the free fraction was not increased to a level as it was expected from direct competitive displacement. The free amlodipine concentration was increased according to increasing the amlodipine concentration when only the BSA was present. When the binding sites were blocked by sufficient amount of arsenic, the increment of free concentration of amlodipine was prominent. When no arsenic was added, the free concentration of amlodipine was only 6.6percent to 10.3percent; whereas this release was 7.65percent to 13.65percent when arsenic was added with an increasing concentration from 1x10-5M to 12x10-5M. This suggests that in the presence of arsenic, the amlodipine is slowly displaced from its high affinity binding site.
Descriptor : EQUILIBRIUM DIALYSIS
Descriptor : AMLODIPINE
Descriptor : ASSOCIATION CONSTANT
Descriptor : BINDING SITE
Descriptor : ARSENIC-AMLODIPINE INTERACTION
Descriptor : CALCIUM CHANNEL BLOCKERS
Added Entry : ABDUL AWAL MD
: SUBHAN N
 
 
 
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