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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62264
Doc. No : 926A
Main Entry : DOUSTAR Y
Title & Author : STUDY OF APOPTOSIS INDUCED BY CALENDULA OFFICINALIS EXTRACT ON EXPERIMENTAL COLON CARCINOMA IN RATS [Article]; NAMVARAN A
Title : MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY
Volume Number : , Vol.20 ؛ No.1
Date : , (2010)
page : : 1 - 5
Abstract : Background: In vitro studies have demonstrated the anticancer effect of Calendula officinalis extract on tumor cell line derived from colorectal cancers. The inhibition ranged from 70-100percent. The aim of this study was to evaluate the apoptosis in epiththelial displastic colon cells following treated with Calendula officinalis extract.Materials and methods: In this experimental study, 56 wistar male rats with age of 12 weeks and 200-300g weight were allocated into two equal groups of treatment and control. For induction of colorectal carcinoma, these two groups were given 1,2-dimethylhydrazine )40mg/kg(, as subcutaneous injection, twice a week for two weeks. Treatment group also was treated with Calendula officinalis extract )200mg/kg/day( orally for 10 weeks. After 10 weeks, distal parts of colon tissue were biopsied in both groups and 3-4 micron tissue section was prepared through TUNEL staining method.Results: Immunohistopathological study reveals that apoptotic cells of displastic colon epithelial cells in treatment group were higher than control group. Mean difference between treatment and control groups were statistically significant )p<0.01(. Conclusion: This study indicated that Calendula officinalis extract would be induced apoptosis of displastic colon cells in experimental colorectal carcinoma of rats.
Descriptor : APOPTOSIS
Descriptor : COLORECTAL CARCINOMA
Descriptor : CALENDULA OFFICINALIS
Added Entry : MOHAJERI D
: FATHIAZAR F
 
 
 
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