خط مشی دسترسیدرباره ما
ثبت نامثبت نام
راهنماراهنما
فارسی
ورودورود
صفحه اصلیصفحه اصلی
جستجوی مدارک
تمام متن
منابع دیجیتالی
رکورد قبلیرکورد بعدی
library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62270
Doc. No : 932A
Main Entry : MANNA S.K
Title & Author : SUB-CHRONIC TOXICITY STUDY OF ALFA-CYPERMETHRIN IN RATS [Article]; KUMAR DAS SH.
Title : IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)
Volume Number : , Vol.5 ؛ No.2
Date : , (2006)
page : : 163 - 166
Abstract : Alfa-cypermethrin )a-CP( a synthetic pyrethroid )type-II( insecticide, dissolved in dimethyl sulfoxide )DMSO-1 mL( was given consecutive daily orally for 60 days at 1/10 LD50 )14.5 mg/kg(. The animals were sacrificed on day 61st. Biochemicals, cytochrome P450, b5 contents in liver along with antioxidant status, tissue residual concentration, and brain GABA level were studied. It increased the serum aminotransami-nase )AST, ALT(, alkaline phosphatase )ALP(, lactate dehydrogenase )LDH( activities and blood glucose level significantly )p<0.05(. It significantly )p<0.05( decreased and increases cytochrome P450 content and b5 content in liver respectively. It increased the malondialdehyde )MDA( level, and decreased the activities of catalase )CAT( and superoxide dismutase )SOD( and glycogen in liver significantly. The py-rethroid was considerable in amount in tissues. The GABA levels in cerebellum and in whole brain without cerebellums were decreased significantly )p<0.05(. Therefore repeated daily oral dose toxicity of a-CP at 1/10 LD50 altered biochemical parameters, decreased cytochrome P450 content, antioxidant status, and decreased brain GABA level.
Descriptor : A-CP
Descriptor : CYTOCHROME P450
Descriptor : ANTIOXIDANTS
Descriptor : TISSUE RESIDUAL CONCENTRATION
Descriptor : BRAIN GABA LEVEL
Descriptor : RAT
Added Entry : BHATTACHARYYA D
: KUMAR MANDAL T
 
 
 
(در صورت عدم وضوح تصویر اینجا را کلیک نمایید)