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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62279
Doc. No : 941A
Main Entry : HADIZADEH FARZIN
Title & Author : SYNTHESIS AND STUDY OF ANTITUMOR ACTIVITY OF SUBSTITUTED IMIDAZOLECARBOXAMIDES [Article]; EGHBALI M
Title : IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume Number : , Vol.3 ؛ No.4
Date : , (2007)
page : : 239 - 244
Abstract : In view of potential biological activities of small molecule polyamides, we synthesized some novel N-)2-aminoethyl(-1-benzyl-2- )alkylthio(-1H-imidazole-5- carboxamide )7a,b(, and N-)2-)1-benzyl-2-)alkylthio( -1H-imidazole- 5-carboxamido( ethyl(-1-benzyl-2- )alkylthio(-1H-imidazole-5-carboxamides )8a,b( as antitumor agents. The antitumor activity of compounds 7a,b and 8a,b was studied at concentrations of 0.01, 0.1 and 1 mg/ml, using the potato disk bioassay technique.Vincristine at 0.25 mg/ml employed as positive control and had -67.24percent tumor inhibition. Maximum percent inhibition for potato tumors was found to be -75.52 for 7b at 1 mg/ml.
Descriptor : ANTITUMOR
Descriptor : IMIDAZOECARBOXAMIDE
Descriptor : POTATO DISC
Added Entry : RAMEZANI MOHAMMAD
: TAYARANI Z
 
 
 
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