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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62288
Doc. No : 950A
Main Entry : KHALILI MOHSEN
Title & Author : THE EFFECT OF AQUEOUS CROCUS SATIVUS L. EXTRACT ON INTRACEREBROVENTRICULAR STREPTOZOTOCIN-INDUCED COGNITIVE DEFICITS IN RAT: A BEHAVIORAL ANALYSIS [Article]
Title : IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)
Volume Number : , Vol.8 ؛ No.3
Date : , (2009)
page : : 185 - 191
Abstract : Intracerebroventricular )ICV( injection of streptozotocin )STZ( causes cognitive impairment in rats. The beneficial effect of Crocus sativus L. extract )CSE( was evaluated on ICV STZ-induced learning, memory, and cognitive impairment in male rats. For this purpose, rats were injected with ICV STZ bilaterally, on days 1 and 3 )3 mg/kg(. The STZ-injected rats received CSE )60 mg/kg; i.p.( every other day, starting one day before surgery, for three weeks. The learning and memory performance was assessed using passive avoidance paradigm, and for spatial cognition evaluation, Y-maze task was used. It was found that CSE-treated STZ-injected rats show higher correct choices and lower errors in Y maze than vehicle-treated STZ-injected rats. In addition, CSE administration significantly attenuated learning and memory impairment in treated STZ-injected group in passive avoidance test. Therefore, these results demonstrate the effectiveness of CSE in preventing the cognitive deficits caused by ICV STZ in rats and its potential in the treatment of neurodegenerative diseases such as Alzheimerعs disease )AD(.
Descriptor : CROCUS SATIVUS L
Descriptor : STREPTOZOTOCIN
Descriptor : LEARNING
Descriptor : MEMORY
Descriptor : SPATIAL COGNITION
Descriptor : RAT
Added Entry : ROGHANI MEHRDAD
: EKHLASI M
 
 
 
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