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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62292
Doc. No : 954A
Main Entry : ARIAEIAN N
Title & Author : THE EFFECT OF CONJUGATED LINOLEIC ACIDS, VITAMIN E AND THEIR COMBINATION ON LIPID PEROXIDATION IN ACTIVE RHEUMATOID ARTHRITIS [Article]; JAZAYERI A.,ESHRAGHIAN M.R.,NADERI N.,FATEHI F.,ZAREEI M.,CHAMARI M.
Title : IRANIAN JOURNAL OF PUBLIC HEALTH
Volume Number : , Vol.38 ؛ No.2
Date : , (2009)
page : : 79 - 89
Abstract : Background: Reactive oxygen species )ROS( have important role in the etiology and pathogenesis of Rheumatoid Arthritis )RA(. We investigated the effect of conjugated linoleic acids )CLAs( and vitamin E on lipid peroxidation.Methods: In a randomized, double-blind placebo, controlled, clinical trial 87 patients with active RA were enrolled. They were divided into 4 groups, received one of the following daily supplement for 3 months; 1- group C: 2.5gr CLA, that contained 2 gr 50:50 mix of cis 9-trans11 and trans 10-cis 12 CLAs, 2- group E: 400mg Vitamin E, 3- group CE: CLAs plus vitamin E, 4- group P: placebo. After supplementation Glutathione peroxidase )GSH-Px( level increased in C, E and CE groups, CE group had lower GSH-Px than P group)P آذ0.05(.Results: Glutathione reductase )GR( increased in CE, C and P groups. Catalase increased in all groups, but enhancement was significant in C and CE. Superoxide dismutase )SOD( decreased in E and C )P آذ0.05(. Catalase and SOD did not show significant differences between groups. Malondialdehyde )MDA( decreased significantly in all groups but this decrease was only significant in CE in comparison with other groups.Conclusion: CLAs might be useful in reducing oxidative stress in RA.
Descriptor : CONJUGATED LINOLEIC ACID
Descriptor : VITAMIN E
Descriptor : LIPID PEROXIDATION
Descriptor : ACTIVE RHEUMATOID ARTHRITIS
Added Entry : JALALI M
: SHAHRAM FARHAD
 
 
 
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