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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62312
Doc. No : 974A
Main Entry : MANSOURI S.M.T
Title & Author : THE EFFECT OF PISTACIA VERA L. GUM EXTRACT ON OXIDATIVE DAMAGE DURING EXPERIMENTAL CEREBRAL ISCHEMIA-REPERFUSION IN RATS [Article]
Title : IRANIAN BIOMEDICAL JOURNAL
Volume Number : , Vol.9 ؛ No.4
Date : , (2005)
page : : 181 - 185
Abstract : Oxygen free radicals may be implicated in the pathogenesis of ischemia reperfusion damage. As the antioxidant effects of some species of Pistacia have been reported, the protective effects of Pistacia vera L. gum extract )0.1-0.5 g/kg( on oxidative damage following cerebral ischemia were studied in rats. Ischemia was induced using four-vessel occlusion model and evaluated using measurement of malondialdehyde )MDA( and antioxidant power in hippocampus. MDA and antioxidant power were assayed with the thiobarbituric acid )TBA( and ferric reducing-antioxidant power )FRAP( tests, respectively. The extract and saline were administered intraperitoneally 10 min subsequent to ischemia. Results have shown that the MDA level increased by 47percent and antioxidant power decreased by 117percent in control group in comparison with sham-operated animals )P< 0.001(. Treatment with P. vera L. gum extract significantly and in a non-dose-dependent manner reduced brain MDA level by 63percent )P<0.001( and increased antioxidant power of brain by 235percent )P<0.001( in comparison to the controls. P. vera L. gum comprised of saponins, tannins, and flavonoids. According to these results, it is suggested that P. vera gum may exhibit neuroprotective effects against ischemia.
Descriptor : PISTACIA VERA
Descriptor : OXIDATIVE STRESS
Descriptor : LIPID PEROXIDATION
Descriptor : GLOBAL ISCHEMIA-REPERFUSION
Descriptor : HIPPOCAMPUS
Added Entry : NAGHIZADEH B
: HOSSEINZADEH H
 
 
 
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