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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62352
Doc. No : 1014A
Main Entry : AHMADI SEYED ALI
Title & Author : THE IMPACT OF LOW SERUM TRIGLYCERIDE ON LDL-CHOLESTEROL ESTIMATION [Article]; TAJIK PARVIN,DIBAJ S.M
Title : ARCHIVES OF IRANIAN MEDICINE
Volume Number : , Vol.11 ؛ No.3
Date : , (2008)
page : : 318 - 321
Abstract : Most clinical laboratories directly measure serum triglyceride, total cholesterol, and highdensity lipoprotein cholesterol. They indirectly calculate low-density lipoprotein cholesterol value using the Friedewald equation. Although high serum triglyceride )>400 mg/dL or 4.52 mmol/L( devaluates low- density lipoprotein cholesterol calculation by using this formula, effects of low serum triglyceride )<100 mg/dL or 1.13 mmol/L( on its accuracy is less defined.Two hundred thirty serum samples were assayed during a one-year period. In 115 samples, the triglyceride level was below 100 mg/dL and in 115 samples from age- and sex-matched patients the triglyceride level was 150 ع 350 mg/dL )1.69 ع 3.95 mmol/L(. In both groups total cholesterol was above 250 mg/dL )6.46 mmol/L(. On each sample, total cholesterol, high-density lipoprotein cholesterol, and triglyceride were directly measured in duplicate and low-density lipoprotein cholesterol measured directly and calculated with Friedewald equation as well.Statistical analysis showed that when triglyceride is <100 mg/dL, calculated low- density lipoprotein cholesterol is significantly overestimated )average :12.17 mg/dL or 0.31 mmol/L(, where as when triglyceride is between 150 and 300 mg/dL no significant difference between calculated and measured low-density lipoprotein cholesterol is observed.In patients with low serum triglyceride and undesirably high total cholesterol levels, Friedewald equation may overestimate low-density lipoprotein cholesterol concentration and it should be either directly assayed or be calculated by a modified Friedewald equation. Using linear regression modeling, we propose a modified equation.
Descriptor : CHOLESTEROL
Descriptor : HDL
Descriptor : LDL
Descriptor : TRIGLYCERIDE
Added Entry : BOROUMAND M.A
: GOUHARI MOGHADAM K
 
 
 
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