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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62362
Doc. No : 1024A
Main Entry : NEYESTANI T.R
Title & Author : THE OPPOSITE ASSOCIATIONS OF LYCOPENE AND BODY FAT MASS WITH HUMORAL IMMUNITY IN TYPE 2 DIABETES MELLITUS: A POSSIBLE ROLE IN ATHEROGENESIS [Article]; KALAEI A.,KHALAJI N
Title : IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)
Volume Number : , Vol.6 ؛ No.2
Date : , (2007)
page : : 79 - 87
Abstract : This study examined the possible effects of lycopene at physiological dosage and body fat mass on the humoral immune response in patients with type 2 diabetes mellitus )T2DM(. A total of 35 patients with Typ 2 diabetes mellitus from both sexes aged 54▒آ9 yrs from the Iranian Diabetes Society were introduced into a double blind placebo controlled clinical trial conducted for 2 months. After a 2-week lycopene free diet washout period, patients were allocated to either lycopene supplementation group )10mg/d( )n=16( or placebo age- and sex matched group )n=19( for 8 weeks. Patients were instructed to keep their diets and physical activities as unchanged as possible. Lycopene supplements increased serum lycopene levels )p<0.001(. While intake of dietary energy and nutrients did not change in either groups, the ratio of total antioxidant capacity to malondialdehyde increased significantly in the lycopene group )p=0.007(. There was an inverse correlation between serum levels of lycopene and those of IgG )r= -0.338, p=0.008(. On the contrary, changes of serum levels of lycopene directly correlated with those of IgM )r=0.466, p=0.005(. Interestingly, changes of the amount of fat mass correlated directly with those of serum IgG )r=0.415, p=0.044( but inversely with of serum IgM )r= -0.469, p=0.021(. While truncal fat might promote adaptive humoral immunity, lycopene probably by inhibiting MDA-LDL formation might attenuate T cell dependent adaptive )pro-atherogenic( humoral immune response. These findings may have preventive implications in long term diabetic complications, notably atherogenesis.
Descriptor : DIABETES MELLITUS TYPE 2
Descriptor : FAT MASS
Descriptor : IMMUNITY
Descriptor : LYCOPENE
Descriptor : OXIDATIVE STRESS FULL TEXT ARTICLE (PDF 228 KB)
Added Entry : SHARIATZADEH N
: GHARAVI A
 
 
 
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