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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62438
Doc. No : 1100A
Main Entry : NAMAYANDEH S.M
Title & Author : VITAMIN E SUPPLEMENT BLOCKS THE RESPONSE OF HDL TO LOVASTATIN THERAPY IN HYPERCHOLESTROLEMIC PATIENTS [Article]; YEGANEH FARD S.,KAMRAN M.,MOTAFAKER M.
Title : ACTA MEDICA IRANICA
Volume Number : , Vol.45 ؛ No.4
Date : , (2007)
page : : 277 - 281
Abstract : HDL can prevent LDL-c oxidation. The low HDL-c State also may benefit clinically from supplemented antioxidant. This study was designed to evaluate the combination therapy of statin and vitamin E in hypercholesterolemic patients. The patients were randomized in a clinical trial aimed to avaluate the effect of vitamin E and/or statin. The life style of patients didnعt alter during intervention. The subjects were randomized to two treatment groups A and B: )1( lovastatin 20mg daily at bedtime. )group A(; )2( vitamin E 400 iu daily plus lovastatin 20mg daily )group B(. The lipid values of each patients at baseline and after 8 weeks of treatment were compared by paired t test. The mean baseline lipid levels for 60 subjects were as follows: plasma cholesterol, triglyceride, LDL-c and HDL-c 285▒آ68, 268▒آ121, 158▒آ32, 49▒آ11 mg/dl respectively. Serum lipid levels changes in group A )statin only( and in group B )statin and vitamin E( were statistically significant. In comparison of lipid profiles changes between two groups we observed that HDL-c changes in group B were significantly lower than in group A. Vitamin E supplement blocks the respons of HDL-c to lovastatin therapy in hypercholestrolemic patients.
Descriptor : VITAMIN E
Descriptor : LOVASTATIN
Descriptor : HYPERCHOLESTROLEMIA
Descriptor : HDL-CHOLESTROL
Added Entry : EMAMI MEYBODI M
: SADR BAFGHI S.M.H
 
 
 
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