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library name : انستیتو تغذیه دانشگاه علوم پزشکی شهید بهشتی
Material Type : Latin Articles
Language of Document : English
Record Number : 62448
Doc. No : 1110A
Main Entry : AMINI SANI N.*
Title & Author : ZINC SUPPLEMENTATION DURING PREGNANCY AND PREGNANCY OUTCOMES: A RANDOMIZED CONTROLLED TRIAL [Article]
Title : IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)
Volume Number : , Vol.8 ؛ No.2
Date : , (2009)
page : : 67 - 71
Abstract : Background: Zinc deficiency during pregnancy has been related to adverse pregnancy outcomes. However, the results of zinc-supplementation trials have not been consistent in improvement of pregnancies outcomes. This study was undertaken to investigate whether zinc supplementation was associated with pregnancy complications in Iranian women during the last 2 trimesters. It also assessed the anthropometric measurements of infants at birth.Methods: A double-blind placebo-controlled trial was conducted in Ardabil province located in northwest of Iran. 196 women between 16-20 weeks عgestation were recruited from urban healthcare centres. These women had no evidence of hypertension, diabetes, renal disease, history of prematurity, premature rupture of membranes )PROM( or low birth weight )LBW( infants. They were randomly assigned to receive zinc )50 mg daily( or placebo until delivery. Basic information was collected on socioeconomic status, reproductive and disease histories before randomization. The subjects were monthly followed during pregnancy and maternal complications were carefully recorded. The weight, length and head circumference of each infant was measured within 24h of birth.Results: Of the 196 women, 17 were excluded from the study )9 in the zinc group and 8 in the placebo group, NS(. The supplementation had no significant effect on prematurity, preeclampcia, PROM and stillbirth as well as gestational age, infant length and head circumference. The incidence of low birth weight was significantly lower in those under Zinc than placebo )p=0.01(. Meanwhile pregnancy-induced hypertension and intrauterine growth retardation )IUGR( were observed only in the placebo group. The birth weight was also higher in the zinc group than the placebo group )p=0.03(.Conclusion: Supplementation with 50mg elemental zinc during pregnancy improved birth weight but did not reduce maternal complications. More evidences on this subject are required in other developing countries.
Descriptor : ZINC SUPPLEMENTATION
Descriptor : PREGNANCY OUTCOME
Descriptor : MATERNAL COMPLICATIONS
 
 
 
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